Carlos A. Zarate Jr., Husseini K. Manji's Bipolar Depression: Molecular Neurobiology, Clinical PDF

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By Carlos A. Zarate Jr., Husseini K. Manji

ISBN-10: 3764385669

ISBN-13: 9783764385668

ISBN-10: 3764385677

ISBN-13: 9783764385675

Even though our wisdom of temper issues often is increasing progressively, relatively little is understood approximately bipolar melancholy particularly. This publication brings jointly best clinicians and preclinical and medical researchers to supply the main up to date information regarding the analysis, remedy, and learn surrounding bipolar melancholy. Early chapters supply invaluable diagnostic details, and evaluation the direction, end result, and genetics of this hugely heritable , permitting clinicians to differentiate among many of the temper issues. The ebook deals an intensive and detailed review of the neurobiology of the illness, together with what's recognized from fresh neuroimaging paintings. a number of chapters delineate the therapy of bipolar melancholy in unique populations equivalent to kids and pregnant ladies, and one other bankruptcy addresses the actual problems with suicide, concentrating on the necessity for evaluation in the course of either acute and upkeep therapy with interventions acceptable to a patient's signs and heritage. eventually, the e-book covers acute and long term remedy innovations for bipolar melancholy, together with either conventional and novel therapeutics for the ailment, in addition to non-pharmacological remedies. This publication has assembled a broadly revered team of preclinical and scientific researchers who convey their services to endure upon this disease. It bargains researchers, clinicians, and postgraduate scholars key insights into this devastating disease.

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Extra info for Bipolar Depression: Molecular Neurobiology, Clinical Diagnosis and Pharmacotherapy (Milestones in Drug Therapy)

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In any attempt to define ‘bipolar depression’ there are three immediate problems. First, it could be defined, as indicated in the ‘top down’ section, by studying those with BPD during the depressed phase. However, this descriptive approach is only of modest value as it lacks specificity. The more substantive second problem is whether bipolar depression is ‘different’ or ‘distinctive’ from unipolar depression, and the issue here is in considering and studying the appropriate reference group. Let us consider the limitations to any comparison with ‘major depression’ or ‘clinical depression’.

There is no significant interaction between stress and episode number in the prediction of bipolar recurrence, and the interaction of early adversity severity and stressful life events significantly predicts recurrence in a manner consistent with the sensitization hypothesis [92]. Few studies have examined the prognostic value of family factors in the course of bipolar disorder. Patients who were more distressed by their relatives’ criticisms had more severe depressive and manic symptoms and proportionately fewer days well [93].

Predictive value of depressive symptoms in the course of bipolar disorder* Onset and index episode • Index mixed episodes have been found to predict relapse into a depressive episode • It is likely that many patients presenting with an index depressive episode are misdiagnosed with unipolar major depression • One third of preadolescents with major depressive disorder experience a manic episode and manifest bipolar disorder within 5 years • Lower initial depression ratings are associated with shorter time to syndromal recovery • A depressive onset is predicted by higher occupational status, initial mixed presentation, and any co-morbidity • Polarity of patients’ first reported mood episode suggests a depression-prone subtype with a greater probability of past suicide attempt • Depressive-onset bipolar disorder is significantly associated with more lifetime depressive episodes and a greater proportion of time with depression and anxiety Course, number and length of episodes • The symptomatic structure of bipolar II disorder is primarily depressive rather than manic • Twice as many patients develop depressive episodes as manic, hypomanic, or mixed episodes • Residual depressive or manic symptoms at recovery and proportion of days depressed are significantly associated with shorter time to depressive recurrence • The longest duration of episodes was found for mixed episodes, while depressive episodes have an intermediate duration and manic episodes are the shortest • 60–70% of manic episodes occur immediately before or after a major depressive episode, and manic episodes often precede or follow the major depressive episodes • Shorter time to a depressive recurrence can be predicted if residual depressive or manic symptoms are still present at recovery • Rapid cycling can be related to a higher number of prior depressive episodes • Patients with psychotic features and those with a greater number of previous depressive episodes were more likely to experience subsyndromal depressive symptoms • 80% of the treatment effect is attributable to the indirect effects of improvements in the depressive symptoms Risk for long term-prognosis • Breakthrough depression represents higher risks for long-term treatment than mania • Every new episode of depression brings a new risk for mania • The risk of depression developing into bipolar disorder remains constant lifelong • Subsyndromal depressive symptoms during the first 2 months after recovery significantly increases the likelihood of depressive relapse Functional Recovery – Outcome • Depressed patients are more impaired than euthymic or hypomanic patients on tests of verbal recall and fine motor skills • Residual depression predicts poorer residential and social/leisure outcomes independent of personality disorders or maladaptive traits • Suicide attempters come mainly from mixed depressives with predominantly Bipolar II base • Subsyndromal depressive symptoms, but not subsyndromal manic or hypomanic symptoms, are associated with significant impairment * All the statements in this table are referenced in the text Course and outcome of bipolar disorder – focusing on depressive aspects 39 Depression Rating Scale like sadness, negative thoughts, detachment, and neurovegetative symptoms, and changes in factor scores are highly correlated with changes in clinical improvement [71].

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Bipolar Depression: Molecular Neurobiology, Clinical Diagnosis and Pharmacotherapy (Milestones in Drug Therapy) by Carlos A. Zarate Jr., Husseini K. Manji

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