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Extra info for Astrocytes. Biochemistry, Physiology, and Pharmacology of Astrocytes
Changes in the local concentration of calcium, low amounts favoring polymerization and high ones depolymerization (Schliwa et al, 1981), could also regulate MT assembly. B. Astrocytes in Situ In mature fibrous astrocytes only a few MT interspersed among the IF are seen in the cytoplasm (Fig. 1), although in precursor cells the MT are very numerous (Peters and Vaughn, 1967; Vaughn and Peters, 1967; Peters et al, 1976). Centrioles are also present in the perikarya of fibrous astrocytes, and single primary cilia embedded in the cytoplasm are commonly seen.
These include the nonmuscle forms of myosin, tropomyosin, and troponin (calmodulin). The functions of similar proteins in muscle contraction and in its regulation by calcium are well understood. It would be interesting to know more about how the interaction of actin with myosin is controlled in astrocytes and other nonmuscle cells and the role in this regulation of calcium and calmodulin, a calcium binding protein which is abundant in brain. , 1977). This ABP, also present in the brain, forms a 1 : 1 complex with soluble actin and thus prevents it from polymerizing.
1984). , 1985) have, however, been detected in astrocytes in culture, and the latter two were shown to increase during astrocyte differentiation. Recently, a new MAP, called MAP 4, which is present in astrocytes (J. B. , 1984). Many of these MAPs form projections on MT that could stabilize MT into bundles or mediate interactions between MT and other organelles (Vallee and Bloom, 1984). Synthesized in a rate-limiting fashion, MAPs could control the rate and extent of MT assembly. Changes in the local concentration of calcium, low amounts favoring polymerization and high ones depolymerization (Schliwa et al, 1981), could also regulate MT assembly.
Astrocytes. Biochemistry, Physiology, and Pharmacology of Astrocytes by Sergey Fedorff (Eds.)