Geriatrics

Download e-book for iPad: Aging Methods and Protocols by Yvonne A. Barnett, Christopher R. Barnett

Posted On April 5, 2018 at 11:01 pm by / Comments Off on Download e-book for iPad: Aging Methods and Protocols by Yvonne A. Barnett, Christopher R. Barnett

By Yvonne A. Barnett, Christopher R. Barnett

ISBN-10: 0896035824

ISBN-13: 9780896035829

Getting older tools and Protocols offers a couple of cutting-edge protocols, defined via famous specialists of their box, that are getting used to additional our realizing of the getting older approach. those special biochemical, actual and molecular biology ideas are mixed to supply a great source for researchers and scientists from a large choice of disciplines. additionally integrated is a presentation of 2 case reports that concentrate on the function of nutritional restrict in existence span extension, in addition to how you can identify and make the most of transgenic animals for the elucidation of the molecular elements of getting older. This e-book is a useful resource of state of the art learn protocols with extensive medical applicability and should curiosity clinical researchers, clinicians concerned inIn this paintings, specialists aspect key biochemical, analytical, and molecular thoughts for the research of getting old on the mobile, tissue, organ, and full method degrees.

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H. (1994) Basal and induced amounts of interleukin 6 mRNA decline progressively with age in human fibroblasts. J. Biol. Chem. 269, 19250–19255. Fibroblast Model for Cell Senescence Studies 47 47. , and Riabowol, K. (1996) Regulation of transcription factor activity during cellular aging. Biochem. Cell Biol. 74, 523–534. 48. , Uzman, J. , Dimri, G. , Nehlin, J. , and Campisi, J. (1996) The helix–loop–helix protein Id-1 and a retinoblastoma protein binding mutant of SV40 T antigen synergize to reactivate DNA synthesis in senescent human fibroblasts.

46 Cristofalo, Volker, and Allen 33. Gorman, S. D. and Cristofalo, V. J. (1985) Reinitiation of cellular DNA synthesis in BrdU-selected nondividing senescent WI-38 cells by simian virus 40 infection. J. Cell. Physiol. 125, 122–126. 34. , Lipson, K. , Cristofalo, V. , and Baserga, R. (1991) Senescent human fibroblasts have a post-transcriptional block in the expression of the proliferating cell nuclear antigen gene. J. Biol. Chem. 266, 8663–8666. 35. Pendergrass, W. , Saulewicz, A. , and Norwood, T.

Kirschner, M. , and Norwood, T. H. (1991) The relationship between the rate of entry into S phase, concentration of DNA polymerase alpha, and cell volume in human diploid fibroblast-like monokaryon cells. Exp. Cell Res. 192, 418–425. 38. Cristofalo, V. J. ), INSERM, Paris, pp. 65–92. 39. Olashaw, N. , Kress, E. , and Cristofalo, V. J. (1983) Thymidine triphosphate synthesis in senescent WI38 cells. Relationship to loss of replicative capacity. Exp. Cell Res. 149, 547–554. 40. Pignolo, R. , Martin, B.

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Aging Methods and Protocols by Yvonne A. Barnett, Christopher R. Barnett


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